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Monitor Carefully (1)pentobarbital will lessen the extent or outcome of glecaprevir/pibrentasvir by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital decreases effects of sufentanil SL by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Carefully. Coadministration of CYP3A4 inducers might reduce sufe